Absolutely . . . the closer you position the ball to low point (closer to left shoulder) the less "out" in the plane . . . has big implications . . . .
In addition how much shaft lean has an effect as well . . . leaning the shaft produces more "out" . . . delofts the face generally . . . and can open the face . . . and increases the angle of attack.
so ball more back = more "out" 'til you get to low point . . . handle forward = more out until you get to low point.
The shaft lean piece (right wrist bend amount) is why Homer didn't make right wrist bend an imperative. The left wrist is always flat . . . but the right wrist bend can will and does vary for ball position and the shot at hand.